Research Projects Pending
Social interaction accelerates speed of extinction and reorientation of cocaine-conditioned place preference
Substitution drug development for drug dependence treatment
The role of nucleus accumbens acetylcholine in the acquisition of drug seeking and consumption of drugs of abuse
Neurotransmitter changes in the cingulate-amygdala- accumbens-cingulate loop in chronic opioid abuse
The role of nucleus accumbens acetylcholine in the acquisition and extinction of drug- vs food reinforcement
Recent Publications:
1:
Nazirizadeh Y, Vogel F, Bader W, Haen E, Pfuhlmann B, Gründer G, Paulzen M,
Schwarz M, Zernig G, Hiemke C. Serum concentrations of paliperidone versus
risperidone and clinical effects. Eur J Clin Pharmacol. 2010 Aug;66(8):797-803.
Epub 2010 Apr 1. PubMed PMID: 20358189.
2: Fritz M, Wallner R, Grohs U, Kemmler G, Saria A, Zernig G. Comparable
sensitivities of urine cotinine and breath carbon monoxide at follow-up time
points of three months or more in a smoking cessation trial. Pharmacology.
2010;85(4):234-40. Epub 2010 Mar 17. PubMed PMID: 20299823.
3: Chenu F, Batten LA, Zernig G, Ladstaetter E, Höbert C, Blier P. Comparison of
pharmacokinetic profiles of brand-name and generic formulations of citalopram and
venlafaxine: a crossover study. J Clin Psychiatry. 2009 Jul;70(7):958-66. PubMed
PMID: 19653973.
4: Kasture S, Vinci S, Ibba F, Puddu A, Marongiu M, Murali B, Pisanu A, Lecca D,
Zernig G, Acquas E. Withania somnifera prevents morphine withdrawal-induced
decrease in spine density in nucleus accumbens shell of rats: a confocal laser
scanning microscopy study. Neurotox Res. 2009 Nov;16(4):343-55. Epub 2009 Jun 24.
PubMed PMID: 19551457.
5: Zernig G, Wallner R, Grohs U, Kriechbaum N, Kemmler G, Saria A. A randomized
trial of short psychotherapy versus sustained-release bupropion for smoking
cessation. Addiction. 2008 Dec;103(12):2024-31. PubMed PMID: 19469746.
6: Kohut SJ, Roma PG, Davis CM, Zernig G, Saria A, Dominguez JM, Rice KC, Riley
AL. The impact of early environmental rearing condition on the discriminative
stimulus effects and Fos expression induced by cocaine in adult male and female
rats. Psychopharmacology (Berl). 2009 Apr;203(2):383-97. Epub 2008 Oct 25. PubMed
PMID: 18953528; PubMed Central PMCID: PMC2661818.
7: Becker A, Grecksch G, Zernig G, Ladstaetter E, Hiemke C, Schmitt U.
Haloperidol and risperidone have specific effects on altered pain sensitivity in
the ketamine model of schizophrenia. Psychopharmacology (Berl). 2009
Mar;202(4):579-87. Epub 2008 Sep 23. PubMed PMID: 18810393.
8: Whitworth A, Stuppaeck C, Yazdi K, Kralovec K, Geretsegger C, Zernig G,
Aichhorn W. Olanzapine and breast-feeding: changes of plasma concentrations of
olanzapine in a breast-fed infant over a period of 5 months. J Psychopharmacol.
2010 Jan;24(1):121-3. Epub 2008 Sep 18. PubMed PMID: 18801835.
9: Rygula R, Abumaria N, Havemann-Reinecke U, Röther E, Hiemke C, Zernig G, Fuchs
E, Flügge G. Pharmacological validation of a chronic social stress model of
depression in rats: effects of reboxetine, haloperidol and diazepam. Behav
Pharmacol. 2008 May;19(3):183-96. PubMed PMID: 18469536.
10: Crespo JA, Stöckl P, Zorn K, Saria A, Zernig G. Nucleus accumbens core
acetylcholine is preferentially activated during acquisition of drug- vs
food-reinforced behavior. Neuropsychopharmacology. 2008 Dec;33(13):3213-20. Epub
2008 Apr 16. PubMed PMID: 18418362.
11: Klier CM, Mossaheb N, Saria A, Schloegelhofer M, Zernig G. Pharmacokinetics
and elimination of quetiapine, venlafaxine, and trazodone during pregnancy and
postpartum. J Clin Psychopharmacol. 2007 Dec;27(6):720-2. PubMed PMID: 18004149.
12: Aichhorn W, Marksteiner J, Walch T, Zernig G, Hinterhuber H, Stuppaeck C,
Kemmler G. Age and gender effects on olanzapine and risperidone plasma
concentrations in children and adolescents. J Child Adolesc Psychopharmacol. 2007
Oct;17(5):665-74. PubMed PMID: 17979586.
13: Zernig G, Ahmed SH, Cardinal RN, Morgan D, Acquas E, Foltin RW, Vezina P,
Negus SS, Crespo JA, Stöckl P, Grubinger P, Madlung E, Haring C, Kurz M, Saria A.
Explaining the escalation of drug use in substance dependence: models and
appropriate animal laboratory tests. Pharmacology. 2007;80(2-3):65-119. Epub 2007
Jun 14. Review. PubMed PMID: 17570954.
14: Acquas E, Pisanu A, Spiga S, Plumitallo A, Zernig G, Di Chiara G.
Differential effects of intravenous R,S-(+/-)-3,4-methylenedioxymethamphetamine
(MDMA, Ecstasy) and its S(+)- and R(-)-enantiomers on dopamine transmission and
extracellular signal regulated kinase phosphorylation (pERK) in the rat nucleus
accumbens shell and core. J Neurochem. 2007 Jul;102(1):121-32. PubMed PMID:
17564678.
15: Ulrich S, Hiemke C, Laux G, Müller-Oerlinghausen B, Havemann-Reinecke U,
Riederer P, Zernig G, Baumann P; TDM group of the Arbeitsgemeinschaft
Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP). Value and actuality of
the prescription information for therapeutic drug monitoring of
psychopharmaceuticals: a comparison with the medico-scientific evidence.
Pharmacopsychiatry. 2007 May;40(3):121-7. PubMed PMID: 17541888.
16: Fridrich P, Colvin HP, Zizza A, Wasan AD, Lukanich J, Lirk P, Saria A, Zernig
G, Hamp T, Gerner P. Phase 1A safety assessment of intravenous amitriptyline. J
Pain. 2007 Jul;8(7):549-55. Epub 2007 May 23. PubMed PMID: 17512256; PubMed
Central PMCID: PMC2001298.
17: Zernig G, Ng K, Hiemke C, Saria A. Therapeutic drug monitoring-based
clozapine dosing recommendations. Ther Drug Monit. 2007 Feb;29(1):130-1. PubMed
PMID: 17304162.
18: Klier CM, Mossaheb N, Lee A, Zernig G. Mirtazapine and breastfeeding:
maternal and infant plasma levels. Am J Psychiatry. 2007 Feb;164(2):348-9. PubMed
PMID: 17267804.
19: Widschwendter CG, Zernig G, Hofer A. Quetiapine cross reactivity with urine
methadone immunoassays. Am J Psychiatry. 2007 Jan;164(1):172. PubMed PMID:
17202566.
20: Crespo JA, Panlilio LV, Schindler CW, Sturm K, Saria A, Zernig G.
Peri-response pharmacokinetics of remifentanil during a self-administration
session indicates that neither blood nor brain levels are titrated. Ann N Y Acad
Sci. 2006 Aug;1074:497-504. PubMed PMID: 17105948.
21: Medja F, Lelievre V, Fontaine RH, Lebas F, Leroux P, Ouimet T, Saria A,
Rougeot C, Dournaud P, Gressens P. Thiorphan, a neutral endopeptidase inhibitor
used for diarrhoea, is neuroprotective in newborn mice. Brain. 2006 Dec;129(Pt
12):3209-23. Epub 2006 Oct 8. PubMed PMID: 17028311.
22: Madlung E, Haring C, Crespo JA, Saria A, Grubinger P, Zernig G. Methadone
doses upon multiple readmissions to inpatient detoxification: Clinical evidence
for very moderate opioid tolerance. Pharmacology. 2006;78(1):38-43. Epub 2006 Aug
15. PubMed PMID: 16912515.
23: Baumann P, Hiemke C, Ulrich S, Eckermann G, Kuss HL, Laux G,
Müller-Oerlingenhausen B, Rao ML, Riederer P, Zernig G; AGNP-TDM;
Arbeitsgemeinschaft fur Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) -
Therapeutic Drug Monitoring (TDM). [Therapeutic drug monitoring (TDM) of
psychotropic drugs: a consensus guideline of the AGNP-TDM group]. Rev Med Suisse.
2006 May 24;2(67):1413-8, 1420-2, 1424-6. Review. French. PubMed PMID: 16786958.
24: Crespo JA, Sturm K, Saria A, Zernig G. Activation of muscarinic and nicotinic
acetylcholine receptors in the nucleus accumbens core is necessary for the
acquisition of drug reinforcement. J Neurosci. 2006 May 31;26(22):6004-10. PubMed
PMID:
16738243.